Antigen processing and presentation of lipid antigen via MHC class Ib

Across TCGA cell cohorts, RNA activity of the Antigen processing and presentation of lipid antigen via MHC class Ib pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNDBP1, SMC5, and AGO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCNDBP1 grouped by Antigen processing and presentation of lipid antigen via MHC class Ib-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCNDBP1 →	-0.310	-0.265	.002	.009	3	4
UPPER_AERODIGESTIVE_TRACT	SMC5 →	-0.358	-0.317	.004	<.001	3	4
SOFT_TISSUE	AGO2 →	+0.274	+0.136	.007	.001	3	3
LUNG_SCLC	ZNF668 →	-0.158	-0.281	.003	.006	3	3
URINARY_TRACT	BAG6 →	-0.257	-0.143	.003	.001	3	3
UPPER_AERODIGESTIVE_TRACT	MEX3B →	+0.169	+0.238	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCNDBP1 by Antigen processing and presentation of lipid antigen via MHC class Ib activity — BLOOD_Myeloma

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