Positive regulation of hemoglobin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of hemoglobin biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IRF2BPL_S659, F5, and KIAA1671_S1488, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hemoglobin biosynthetic process activity versus IRF2BPL_S659 in BRCA (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IRF2BPL_S659 →	-0.574	-0.070	.001	<.001	3	5
GBM	F5 →	+0.563	+0.071	.005	.003	3	5
CCRCC	KIAA1671_S1488 →	+0.393	+0.052	<.001	<.001	3	5
PDAC	LYAR →	-0.210	-0.048	.006	.001	3	5
BRCA	SP100_S171 →	+0.420	+0.076	.002	<.001	3	4
BRCA	ADD1_S358 →	+0.868	+0.062	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046985 vs IRF2BPL_S659 — BRCA

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