Positive regulation of hemoglobin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of hemoglobin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD27, ZBED2, and LINC02397, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hemoglobin biosynthetic process activity versus CD27 in LSCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD27 →	-0.541	-0.452	.009	.003	3	4
LSCC	ZBED2 →	-1.275	-0.597	<.001	<.001	3	4
LUAD	LINC02397 →	-0.300	-0.277	.001	.007	3	4
LUAD	IGLV5-45 →	-1.569	-0.336	<.001	.001	3	4
BRCA	GSTA4 →	+0.896	+0.588	.001	.001	3	4
BRCA	IGKV1-16 →	-1.528	-0.509	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046985 vs CD27 — LSCC

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