Positive regulation of hemoglobin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of hemoglobin biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRMT1, ACCS, and ABCC13, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRMT1 grouped by Positive regulation of hemoglobin biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRMT1 →	-0.326	-0.298	.002	.004	2	8
CNS	ACCS →	-0.250	-0.824	.001	.002	3	5
CNS	ABCC13 →	-0.266	-0.887	.001	.008	3	5
BLOOD_Leukemia	ABCB10 →	-0.235	-0.310	.001	<.001	3	4
CNS	KLF4 →	-0.352	-0.675	<.001	.009	2	5
CNS	PAMR1 →	-0.165	-0.553	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRMT1 by Positive regulation of hemoglobin biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →