Positive regulation of hemoglobin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of hemoglobin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UTP18, GOLGA8O, and ERMP1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hemoglobin biosynthetic process activity versus UTP18 in LUNG_SCLC (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UTP18 →	+0.809	+0.314	.004	.002	3	2
LUNG_SCLC	GOLGA8O →	-0.619	-0.314	.001	.002	3	2
BLOOD_Leukemia	ERMP1 →	-1.450	-0.612	.002	.003	3	1
LUNG_SCLC	GSTZ1 →	+1.270	+0.416	.001	.006	3	1
LUNG_SCLC	GSKIP →	+1.146	+0.462	<.001	<.001	3	1
LUNG_SCLC	SMCHD1 →	+0.916	+0.314	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046985 vs UTP18 — LUNG_SCLC

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