Regulation of hemoglobin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of hemoglobin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM1P29, LGMN, and WNT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hemoglobin biosynthetic process activity versus NPM1P29 in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NPM1P29 →	+0.451	+0.389	.008	<.001	3	4
BRCA	LGMN →	-0.459	-0.488	.002	.001	3	3
BRCA	WNT2 →	-0.665	-0.578	.002	<.001	3	3
LSCC	RIPOR2 →	-0.704	-0.552	.004	.002	3	3
BRCA	GPR174 →	-0.708	-0.601	.007	<.001	3	3
LSCC	SLC7A7 →	-0.600	-0.500	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046984 vs NPM1P29 — HNSC

Explore this scatter interactively →