Regulation of hemoglobin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of hemoglobin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGMAR1, LSM8, and KLF11, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIGMAR1 grouped by Regulation of hemoglobin biosynthetic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SIGMAR1 →	+0.641	+0.194	.004	.001	3	3
URINARY_TRACT	LSM8 →	-0.896	-0.246	.006	.001	3	3
URINARY_TRACT	KLF11 →	-2.420	-0.364	.004	.004	3	3
SKIN	MMGT1 →	-0.634	-0.223	.001	.004	3	2
SKIN	PPM1D →	-0.544	-0.219	.004	<.001	2	3
LUNG_NSCLC_LUAD	CIART →	-1.612	-0.265	.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIGMAR1 by Regulation of hemoglobin biosynthetic process activity — PANCREAS

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