Ketone body biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ketone body biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMM8B, CAMSAP3_S780, and CTNNA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone body biosynthetic process activity versus TIMM8B in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMM8B →	+0.396	+0.060	.001	<.001	3	5
BRCA	CAMSAP3_S780 →	+0.955	+0.089	.005	<.001	3	5
GBM	CTNNA1 →	+0.369	+0.074	.001	.002	3	5
LSCC	DOCK10 →	-0.396	-0.073	<.001	.001	3	5
GBM	ACAN →	-0.446	-0.055	.003	<.001	3	5
CCRCC	VASH1_S313 →	-0.453	-0.083	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046951 vs TIMM8B — BRCA

Explore this scatter interactively →