Ketone body biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ketone body biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSS3, AOX1, and DLG2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone body biosynthetic process activity versus ACSS3 in BRCA (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACSS3 →	+1.161	+0.181	<.001	<.001	3	6
HNSC	AOX1 →	+0.775	+0.100	.002	.001	3	6
HNSC	DLG2 →	+0.664	+0.219	<.001	<.001	3	6
PDAC	ASPA →	+0.601	+0.092	<.001	<.001	3	6
BRCA	CDC20 →	-1.094	-0.138	<.001	<.001	3	5
LSCC	TCF21 →	+0.543	+0.147	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046951 vs ACSS3 — BRCA

Explore this scatter interactively →