Ketone body biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ketone body biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEGS2, ADCK5, and MYO9B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone body biosynthetic process activity versus DEGS2 in BREAST (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DEGS2 →	+2.928	+1.180	.008	.002	3	4
BREAST	ADCK5 →	+1.074	+1.152	.001	<.001	3	4
BLOOD_Leukemia	MYO9B →	-1.165	-1.732	.003	<.001	3	3
BLOOD_Lymphoma	GSTM1 →	-5.356	-1.941	<.001	<.001	3	3
KIDNEY	TRIM73 →	+1.995	+1.738	.006	.009	3	3
BREAST	CMTM7 →	-2.269	-1.023	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046951 vs DEGS2 — BREAST

Explore this scatter interactively →