Fatty-acyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Fatty-acyl-CoA biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TSFM, MMP2, and TPM4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty-acyl-CoA biosynthetic process activity versus TSFM in PDAC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TSFM →	+0.317	+0.035	<.001	.002	3	7
LSCC	MMP2 →	-0.842	-0.057	<.001	<.001	3	6
LSCC	TPM4 →	-0.453	-0.050	<.001	<.001	3	6
PDAC	MRPL44 →	+0.241	+0.030	.001	.006	2	7
LSCC	TRAP1 →	+0.371	+0.030	.001	.006	3	6
CCRCC	SGCD →	-0.533	-0.041	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046949 vs TSFM — PDAC

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