Fatty-acyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Fatty-acyl-CoA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCD, SCN4A, and NMRAL2P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty-acyl-CoA biosynthetic process activity versus SCD in OV (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SCD →	+0.859	+0.172	.003	<.001	3	4
HNSC	SCN4A →	-0.482	-0.103	.007	.008	3	4
CCRCC	NMRAL2P →	+0.962	+0.121	.002	.006	3	4
LSCC	FSD1 →	-0.657	-0.174	.001	<.001	3	3
COAD	SMO →	-0.670	-0.169	.003	<.001	2	4
BRCA	C19orf12 →	-0.428	-0.213	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046949 vs SCD — OV

Explore this scatter interactively →