Fatty-acyl-CoA biosynthetic process

Across TCGA cell cohorts, RNA activity of the Fatty-acyl-CoA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LASP1, SLMAP, and BIN3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LASP1 grouped by Fatty-acyl-CoA biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LASP1 →	-1.063	-1.316	.002	.002	3	5
SOFT_TISSUE	SLMAP →	-0.766	-1.252	.001	<.001	3	4
SKIN	BIN3 →	+1.070	+1.377	.003	<.001	3	4
SKIN	S100A3 →	-1.811	-0.819	<.001	.003	3	4
BREAST	FOXP1 →	-0.865	-0.895	.009	.007	2	5
STOMACH	CAV1 →	-4.798	-1.365	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LASP1 by Fatty-acyl-CoA biosynthetic process activity — STOMACH

Explore this box plot interactively →