Pore complex assembly

Across TCGA patient cohorts, RNA activity of the Pore complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DHX38, EDC4, and LIMA1_S686, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pore complex assembly activity versus DHX38 in LSCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DHX38 →	+0.154	+0.037	.006	.001	3	5
OV	EDC4 →	+0.210	+0.050	<.001	<.001	3	5
HNSC	LIMA1_S686 →	-0.535	-0.070	<.001	.002	3	5
LSCC	CA12 →	-0.889	-0.038	.002	.002	3	5
CCRCC	EPB41L2_S718 →	+0.583	+0.036	<.001	<.001	3	4
COAD	USP1_S327 →	+0.605	+0.056	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046931 vs DHX38 — LSCC

Explore this scatter interactively →