Pore complex assembly

Across TCGA patient cohorts, RNA activity of the Pore complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC2, ATL2, and KIF18A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pore complex assembly activity versus DNAJC2 in BRCA (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DNAJC2 →	+0.539	+0.886	<.001	<.001	3	5
BRCA	ATL2 →	+0.517	+0.579	<.001	<.001	3	5
LSCC	KIF18A →	+0.634	+0.518	<.001	.003	3	5
LSCC	HMGA1 →	+0.859	+0.773	<.001	<.001	3	5
BRCA	SFRP2 →	-1.211	-0.643	<.001	<.001	3	5
BRCA	RASGRP4 →	-0.408	-0.700	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046931 vs DNAJC2 — BRCA

Explore this scatter interactively →