Pore complex assembly

Across TCGA cell cohorts, RNA activity of the Pore complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC3, ATP8B1, and CPEB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pore complex assembly activity versus KLHDC3 in PANCREAS (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KLHDC3 →	+0.718	+0.198	.001	.001	3	5
LUNG_SCLC	ATP8B1 →	-1.886	-0.206	.009	.001	3	5
PANCREAS	CPEB2 →	-1.785	-0.241	.002	.006	3	4
PANCREAS	ATG16L1 →	-0.881	-0.229	.003	.003	3	4
SOFT_TISSUE	PARP11 →	+1.016	+0.335	.006	<.001	3	4
BREAST	TRIM21 →	+0.912	+0.168	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046931 vs KLHDC3 — PANCREAS

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