Negative regulation of neurotransmitter secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of neurotransmitter secretion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NF1, C17orf75, and RND2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neurotransmitter secretion activity versus NF1 in HNSC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NF1 →	+0.676	+0.860	<.001	<.001	3	5
LSCC	C17orf75 →	+0.488	+0.709	.004	.003	3	4
LSCC	RND2 →	+0.618	+0.725	.009	<.001	3	4
LSCC	NAPB →	+0.295	+0.739	.007	<.001	3	4
GBM	OMG →	+0.844	+0.607	<.001	<.001	3	4
LSCC	TMEM99 →	+0.609	+0.805	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046929 vs NF1 — HNSC

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