Negative regulation of neurotransmitter secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of neurotransmitter secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WWC2, NPIPB15, and PDGFB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WWC2 grouped by Negative regulation of neurotransmitter secretion-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	WWC2 →	+2.408	+1.606	.006	.001	3	4
UPPER_AERODIGESTIVE_TRACT	NPIPB15 →	-2.679	-0.752	.005	<.001	2	5
SKIN	PDGFB →	+1.950	+0.939	.002	.002	3	4
SKIN	B3GNT5 →	+1.183	+0.909	.006	.004	3	4
BONE	DYNC2I2 →	+1.064	+1.157	.009	.009	3	4
STOMACH	XPC →	-0.695	-1.061	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WWC2 by Negative regulation of neurotransmitter secretion activity — BLOOD_Myeloma

Explore this box plot interactively →