Negative regulation of neurotransmitter secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of neurotransmitter secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35C2, SLC25A17, and PPP1R35, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neurotransmitter secretion activity versus SLC35C2 in LUNG_SCLC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC35C2 →	+0.639	+1.114	.007	.001	3	3
LUNG_NSCLC_LUSC	SLC25A17 →	-0.907	-0.446	.007	.004	3	3
OESOPHAGUS	PPP1R35 →	-2.044	-0.642	<.001	.003	3	3
KIDNEY	ZSCAN22 →	+0.576	+0.504	.003	.006	3	3
BREAST	ADORA2A →	+1.435	+0.942	.001	.002	3	3
LUNG_NSCLC_LUAD	MAPK8IP2 →	-1.140	-0.709	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046929 vs SLC35C2 — LUNG_SCLC

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