Regulation of neurotransmitter secretion

Across TCGA cell cohorts, RNA activity of the Regulation of neurotransmitter secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGCS2, VWA8, and CLCN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter secretion activity versus HMGCS2 in BLOOD_Leukemia (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HMGCS2 →	-0.038	-0.603	.003	<.001	3	5
LARGE_INTESTINE	VWA8 →	-0.634	-0.636	<.001	<.001	3	4
SOFT_TISSUE	CLCN2 →	-1.012	-0.981	<.001	.008	3	4
SOFT_TISSUE	GNL3 →	-0.634	-0.981	.007	.008	3	4
LIVER	TGFB2 →	+4.422	+2.225	.002	<.001	3	4
BLOOD_Leukemia	EML4 →	-0.751	-0.411	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046928 vs HMGCS2 — BLOOD_Leukemia

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