Regulation of mitochondrial membrane permeability

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial membrane permeability pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP12_T1116, JPT1_S131, and RPL4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial membrane permeability activity versus AKAP12_T1116 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKAP12_T1116 →	+0.851	+0.030	<.001	.001	3	4
PDAC	JPT1_S131 →	-0.563	-0.019	.003	.004	3	4
GBM	RPL4 →	-0.304	-0.031	.002	<.001	3	4
GBM	RPL5 →	-0.155	-0.026	<.001	<.001	3	4
LSCC	SPAG9 →	-0.105	-0.025	.003	.001	3	4
BRCA	THRAP3_S253 →	-0.634	-0.027	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046902 vs AKAP12_T1116 — BRCA

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