Regulation of mitochondrial membrane permeability

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3CD, RAB40AL, and RRAGC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIK3CD grouped by Regulation of mitochondrial membrane permeability-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PIK3CD →	-1.833	-1.275	.004	.001	3	5
CNS	RAB40AL →	-0.224	-0.991	<.001	<.001	3	5
BLOOD_Myeloma	RRAGC →	-0.957	-1.747	.001	.001	3	4
LUNG_NSCLC_LUSC	SORBS3 →	-1.143	-1.614	.002	<.001	3	4
LUNG_NSCLC_LUSC	MCCC2 →	+0.985	+2.008	.002	<.001	3	4
LUNG_NSCLC_LUSC	DAB2 →	-2.794	-1.587	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIK3CD by Regulation of mitochondrial membrane permeability activity — BLOOD_Leukemia

Explore this box plot interactively →