Regulation of mitochondrial membrane permeability

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD4, EBP, and GLA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial membrane permeability activity versus ABHD4 in BONE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ABHD4 →	+1.886	+0.305	.003	.001	3	6
OVARY	EBP →	+2.217	+0.308	.002	.002	3	6
LIVER	GLA →	+1.445	+0.262	.006	.001	3	4
LUNG_NSCLC_LUAD	PTGR1 →	+1.989	+0.172	<.001	<.001	3	4
LUNG_NSCLC_LUAD	LYPLA2 →	-0.684	-0.182	<.001	.001	3	4
BLOOD_Leukemia	RPAIN →	-0.747	-0.135	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046902 vs ABHD4 — BONE

Explore this scatter interactively →