Negative regulation of hormone secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of hormone secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAT5, USP27X, and LUC7L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hormone secretion activity versus KAT5 in BLOOD_Myeloma (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KAT5 →	+0.701	+0.221	.001	.004	3	6
BREAST	USP27X →	+0.688	+0.170	.001	.005	3	5
BREAST	LUC7L →	+0.729	+0.204	.003	.004	3	5
BLOOD_Myeloma	CIPC →	+1.118	+0.271	.003	<.001	3	5
BLOOD_Lymphoma	BTBD19 →	-0.705	-0.207	.006	<.001	3	5
BLOOD_Myeloma	SETD1B →	+1.114	+0.274	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046888 vs KAT5 — BLOOD_Myeloma

Explore this scatter interactively →