Positive regulation of hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLXDC2, ADM, and EGR1, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hormone biosynthetic process activity versus PLXDC2 in THYM (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	PLXDC2 →	+1.546	+0.088	<.001	<.001	3	27
DLBC	ADM →	+1.898	+0.073	.002	.003	2	27
KICH	EGR1 →	+1.959	+0.060	<.001	<.001	3	26
TGCT	HIVEP2 →	+0.981	+0.079	<.001	<.001	3	25
ACC	CHSY1 →	+1.611	+0.079	<.001	<.001	2	26
TGCT	THBS1 →	+1.800	+0.083	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046886 vs PLXDC2 — THYM

Explore this scatter interactively →