Positive regulation of hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLT8D2, RAB3IL1, and MN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hormone biosynthetic process activity versus GLT8D2 in COAD (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GLT8D2 →	+0.540	+0.245	.007	.002	2	6
LUAD	RAB3IL1 →	+0.401	+0.270	.004	.003	3	5
LSCC	MN1 →	+0.784	+0.449	<.001	.001	3	5
HNSC	ITGA11 →	+0.735	+0.489	.002	.005	3	5
BRCA	ARRDC1 →	-0.830	-0.667	.001	.001	3	4
LUAD	PRRX1 →	+0.746	+0.370	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046886 vs GLT8D2 — COAD

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