Positive regulation of hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC10A3, RSL24D1, and CTTNBP2NL, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hormone biosynthetic process activity versus SLC10A3 in BONE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SLC10A3 →	+1.092	+0.332	.002	.006	3	2
BONE	RSL24D1 →	-0.737	-0.332	.007	.006	3	2
BONE	CTTNBP2NL →	+1.104	+0.332	.003	.006	3	2
BONE	TK1 →	+1.836	+0.483	.007	.002	3	2
BONE	PLEC →	+2.380	+0.430	.004	.006	3	2
BONE	C8orf76 →	+0.685	+0.332	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046886 vs SLC10A3 — BONE

Explore this scatter interactively →