Regulation of hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of hormone biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are F12, PLEC, and RSU1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hormone biosynthetic process activity versus F12 in CCRCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	F12 →	+0.443	+0.048	<.001	.003	3	7
BRCA	PLEC →	+0.358	+0.041	.001	.001	3	6
BRCA	RSU1 →	+0.284	+0.044	<.001	<.001	3	6
BRCA	SERPINA10 →	+0.425	+0.032	<.001	<.001	3	6
BRCA	SRPX2 →	+0.933	+0.051	<.001	<.001	3	6
GBM	C8A →	+0.808	+0.083	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046885 vs F12 — CCRCC

Explore this scatter interactively →