Regulation of hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H6PD, POFUT2, and CHPF2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hormone biosynthetic process activity versus H6PD in CNS (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	H6PD →	+1.094	+0.130	<.001	<.001	3	14
LUNG_SCLC	POFUT2 →	+0.813	+0.159	.002	<.001	3	12
LUNG_NSCLC_LUAD	CHPF2 →	+1.084	+0.092	<.001	<.001	3	11
LUNG_SCLC	EGR1 →	+2.483	+0.154	.001	.004	3	11
BONE	CPQ →	+2.373	+0.129	<.001	<.001	3	11
SKIN	MXD4 →	+1.200	+0.089	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046885 vs H6PD — CNS

Explore this scatter interactively →