Regulation of hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLID, TMEM191C, and RBM14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hormone biosynthetic process activity versus BLID in OVARY (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BLID →	-0.125	-0.819	.005	<.001	3	5
BLOOD_Leukemia	TMEM191C →	+0.733	+1.203	.002	.005	3	4
BLOOD_Lymphoma	RBM14 →	-0.773	-1.654	.001	.001	3	4
LUNG_SCLC	DUSP9 →	+1.750	+0.397	<.001	.008	3	4
LUNG_NSCLC_LUAD	SH2B3 →	-1.380	-0.466	<.001	.003	3	4
BLOOD_Leukemia	DNAJB11 →	+0.750	+1.140	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046885 vs BLID — OVARY

Explore this scatter interactively →