Regulation of saliva secretion

Across TCGA patient cohorts, RNA activity of the Regulation of saliva secretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPSAP72, INKA2-AS1, and RNU1-72P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of saliva secretion activity versus RPSAP72 in GBM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPSAP72 →	+0.581	+0.529	.007	<.001	3	3
LSCC	INKA2-AS1 →	+0.115	+0.627	<.001	<.001	3	3
HNSC	RNU1-72P →	-0.697	-0.373	.006	.004	3	3
GBM	F13A1 →	-1.684	-0.504	.003	.008	3	3
GBM	ZNF132 →	+0.463	+0.492	.001	.005	3	3
GBM	SNAP25 →	+1.284	+0.470	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046877 vs RPSAP72 — GBM

Explore this scatter interactively →