Regulation of saliva secretion

Across TCGA cell cohorts, RNA activity of the Regulation of saliva secretion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF1B, YIF1A, and NREP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF1B grouped by Regulation of saliva secretion-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KIF1B →	+0.787	+1.182	.009	<.001	3	4
PANCREAS	YIF1A →	-0.667	-1.255	<.001	<.001	3	4
LUNG_NSCLC_LUSC	NREP →	+3.242	+1.332	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ZNF764 →	+0.637	+1.079	.002	.003	3	4
BLOOD_Leukemia	BAZ2B →	+1.230	+0.774	.001	.006	3	4
STOMACH	ELF2 →	+0.705	+1.538	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF1B by Regulation of saliva secretion activity — OESOPHAGUS

Explore this box plot interactively →