Regulation of saliva secretion

Across TCGA cell cohorts, RNA activity of the Regulation of saliva secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EZH2, AGFG2, and PPP1R16B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EZH2 grouped by Regulation of saliva secretion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	EZH2 →	-0.280	-1.300	.006	.001	3	4
BREAST	AGFG2 →	-0.181	-0.583	.005	.003	3	4
SOFT_TISSUE	PPP1R16B →	-0.337	-2.316	.002	<.001	3	4
SOFT_TISSUE	TCTE1 →	-0.234	-1.738	<.001	.008	3	3
OVARY	SLC16A13 →	-0.346	-1.418	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	HCCS →	-0.290	-0.262	.009	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EZH2 by Regulation of saliva secretion activity — LUNG_SCLC

Explore this box plot interactively →