Phosphatidylinositol dephosphorylation

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF13, OSBPL2, and TMEM182, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHF13 grouped by Phosphatidylinositol dephosphorylation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHF13 →	+1.019	+1.161	<.001	<.001	3	4
BLOOD_Myeloma	OSBPL2 →	+0.725	+1.930	.002	<.001	3	4
LIVER	TMEM182 →	+0.989	+1.193	.008	.004	2	5
BONE	PHB →	+0.750	+1.081	.003	.005	3	4
BLOOD_Leukemia	EDC3 →	+0.816	+0.999	<.001	<.001	3	4
BREAST	FASTKD1 →	+0.936	+0.625	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHF13 by Phosphatidylinositol dephosphorylation activity — BLOOD_Leukemia

Explore this box plot interactively →