Phosphatidylinositol dephosphorylation

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTMR9, SYNJ1, and RNGTT, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol dephosphorylation activity versus MTMR9 in LIVER (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MTMR9 →	+0.752	+0.099	.003	<.001	3	17
OESOPHAGUS	SYNJ1 →	+1.133	+0.088	.001	.003	2	18
OVARY	RNGTT →	+0.679	+0.053	.001	<.001	3	16
BLOOD_Lymphoma	TNKS2 →	+0.715	+0.033	.003	.001	3	15
OVARY	MORC3 →	+0.837	+0.060	<.001	.001	3	15
SOFT_TISSUE	TAOK1 →	+0.712	+0.043	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046856 vs MTMR9 — LIVER

Explore this scatter interactively →