Phosphatidylinositol dephosphorylation

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF639, CAMK2D, and SPRY4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol dephosphorylation activity versus ZNF639 in OESOPHAGUS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF639 →	+1.200	+1.208	.001	<.001	3	5
CNS	CAMK2D →	-1.287	-0.569	<.001	.009	3	4
CNS	SPRY4 →	-2.228	-1.191	.001	<.001	3	4
OVARY	POGLUT2 →	-1.267	-0.870	.002	<.001	3	4
KIDNEY	ZDHHC24 →	+0.833	+1.221	.002	.001	3	4
LIVER	CLCN6 →	+1.114	+1.161	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046856 vs ZNF639 — OESOPHAGUS

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