Phosphatidylinositol phosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylinositol phosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, RCSD1, and SEPTIN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol phosphate biosynthetic process activity versus CLIC2 in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLIC2 →	+0.546	+0.051	<.001	<.001	3	10
BRCA	RCSD1 →	+0.570	+0.036	<.001	<.001	3	9
LSCC	SEPTIN1 →	+0.664	+0.066	<.001	<.001	3	9
LSCC	BTK →	+0.494	+0.061	<.001	<.001	3	9
LSCC	CORO1A →	+0.522	+0.071	<.001	<.001	3	9
LSCC	DOCK10 →	+0.411	+0.064	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046854 vs CLIC2 — UCEC

Explore this scatter interactively →