Phosphatidylinositol phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol phosphate biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL6R, MASP2, and ARPIN-AP3S2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL6R grouped by Phosphatidylinositol phosphate biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IL6R →	-0.463	-1.710	.001	.008	3	4
LUNG_NSCLC_LUAD	MASP2 →	+0.227	+1.038	.006	<.001	3	3
LUNG_NSCLC_LUAD	ARPIN-AP3S2 →	+0.174	+1.073	.001	.003	3	3
CNS	BLZF1 →	+0.173	+0.901	<.001	<.001	3	3
LUNG_NSCLC_LUAD	G6PC2 →	+0.140	+1.208	.004	.004	3	3
KIDNEY	NMRAL1 →	+0.345	+1.202	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL6R by Phosphatidylinositol phosphate biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →