Phosphatidylinositol phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL15, SLC25A32, and UQCRB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol phosphate biosynthetic process activity versus MRPL15 in BONE (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MRPL15 →	+1.033	+1.347	.008	<.001	3	5
LUNG_SCLC	SLC25A32 →	+0.669	+1.060	.001	<.001	3	5
OESOPHAGUS	UQCRB →	+0.912	+1.107	.001	.002	3	4
BONE	NSMAF →	+1.095	+1.440	.001	.001	3	4
BONE	ATP6V1H →	+1.374	+1.444	.004	<.001	3	4
CNS	PABPC1 →	+0.699	+0.671	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046854 vs MRPL15 — BONE

Explore this scatter interactively →