Regulation of bone remodeling

Across TCGA patient cohorts, RNA activity of the Regulation of bone remodeling pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIP4, ITGAX, and MILR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of bone remodeling activity versus CLIP4 in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLIP4 →	+0.872	+0.320	<.001	<.001	3	6
GBM	ITGAX →	+0.896	+0.284	<.001	<.001	3	6
UCEC	MILR1 →	+0.897	+0.217	.009	.005	3	6
GBM	FCGR2A →	+0.919	+0.255	<.001	.001	3	6
UCEC	SFPQ →	-0.353	-0.157	<.001	.008	3	5
GBM	LGALS9 →	+0.545	+0.257	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046850 vs CLIP4 — UCEC

Explore this scatter interactively →