Regulation of bone remodeling

Across TCGA cell cohorts, RNA activity of the Regulation of bone remodeling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO11, SRSF12, and ZNF711, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO11 grouped by Regulation of bone remodeling-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FBXO11 →	+0.693	+1.119	.001	.001	3	4
SOFT_TISSUE	SRSF12 →	+1.177	+0.766	.007	.007	3	4
CNS	ZNF711 →	+1.521	+0.953	.001	.001	3	3
CNS	TMEM145 →	+0.695	+0.835	.007	.006	3	3
LUNG_NSCLC_LUSC	YY2 →	-0.993	-1.236	.002	<.001	3	3
PANCREAS	DOCK11 →	+1.304	+0.932	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO11 by Regulation of bone remodeling activity — STOMACH

Explore this box plot interactively →