Regulation of bone remodeling

Across TCGA cell cohorts, RNA activity of the Regulation of bone remodeling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRY1, GUCD1, and SLC4A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of bone remodeling activity versus CRY1 in BLOOD_Lymphoma (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CRY1 →	-2.861	-0.957	<.001	.001	3	4
SKIN	GUCD1 →	+0.919	+1.354	<.001	<.001	3	3
SKIN	SLC4A2 →	+1.222	+1.305	<.001	<.001	3	3
SKIN	KCNE5 →	-0.180	-0.904	.005	.003	3	3
BREAST	SPTLC1 →	-0.924	-0.946	<.001	.008	3	3
BREAST	TAF8 →	-0.687	-0.793	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046850 vs CRY1 — BLOOD_Lymphoma

Explore this scatter interactively →