Bone remodeling

Across TCGA patient cohorts, RNA activity of the Bone remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANKRD44, OLFML1, and PIP4K2A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone remodeling activity versus ANKRD44 in OV (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ANKRD44 →	+0.580	+0.051	<.001	<.001	3	10
UCEC	OLFML1 →	+0.787	+0.047	.001	.003	3	10
GBM	PIP4K2A →	+0.636	+0.074	<.001	<.001	3	10
LSCC	WDR36 →	-0.293	-0.057	<.001	<.001	3	9
BRCA	WIPF1 →	+0.410	+0.034	<.001	<.001	3	9
GBM	DAB2 →	+0.805	+0.078	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046849 vs ANKRD44 — OV

Explore this scatter interactively →