Bone remodeling

Across TCGA patient cohorts, RNA activity of the Bone remodeling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFPT2, TSHZ3, and VSIG4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone remodeling activity versus GFPT2 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GFPT2 →	+1.398	+0.316	<.001	.002	3	8
OV	TSHZ3 →	+0.632	+0.217	<.001	.003	3	7
GBM	VSIG4 →	+1.225	+0.223	<.001	<.001	3	7
OV	ITGA5 →	+1.315	+0.375	<.001	<.001	3	7
GBM	CTSB →	+0.776	+0.198	<.001	<.001	3	7
BRCA	C1S →	+0.890	+0.277	.002	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046849 vs GFPT2 — OV

Explore this scatter interactively →