Bone remodeling

Across TCGA cell cohorts, RNA activity of the Bone remodeling pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIC3, SERAC1, and KLHL7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLIC3 grouped by Bone remodeling-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CLIC3 →	-2.109	-0.910	.001	.006	3	5
LUNG_NSCLC_LUSC	SERAC1 →	-0.746	-1.193	.001	.007	3	4
LUNG_NSCLC_LUSC	KLHL7 →	-0.659	-1.033	.006	.007	3	4
SKIN	FAXC →	-0.879	-0.722	.005	.003	3	4
SOFT_TISSUE	DDX58 →	+1.390	+1.133	.004	.003	3	4
OESOPHAGUS	PLAAT3 →	-2.220	-0.865	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLIC3 by Bone remodeling activity — OVARY

Explore this box plot interactively →