Bone remodeling

Across TCGA cell cohorts, RNA activity of the Bone remodeling pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCM1, NACA, and TPP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone remodeling activity versus PCM1 in OESOPHAGUS (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PCM1 →	-0.865	-1.212	.003	.001	3	5
STOMACH	NACA →	-0.908	-1.199	.005	.005	3	5
OESOPHAGUS	TPP1 →	+1.118	+1.360	.006	<.001	3	5
BLOOD_Leukemia	CTSA →	+0.944	+0.251	.001	<.001	3	4
SOFT_TISSUE	CAVIN3 →	+4.738	+1.755	.001	<.001	2	5
LARGE_INTESTINE	SLC25A19 →	-0.617	-0.665	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046849 vs PCM1 — OESOPHAGUS

Explore this scatter interactively →