Filopodium assembly

Across TCGA patient cohorts, RNA activity of the Filopodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND3, ADCY7, and ZNF366, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Filopodium assembly activity versus DENND3 in LUSC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	DENND3 →	+0.861	+0.036	<.001	<.001	3	31
SCLC	ADCY7 →	+1.232	+0.082	<.001	<.001	3	31
SCLC	ZNF366 →	+0.853	+0.102	<.001	<.001	3	31
LUSC	CSF2RB →	+1.498	+0.043	<.001	<.001	3	30
LAML	LILRB1 →	+1.586	+0.037	<.001	<.001	3	30
UVM	IL10RA →	+2.058	+0.032	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046847 vs DENND3 — LUSC

Explore this scatter interactively →