Filopodium assembly

Across TCGA cell cohorts, RNA activity of the Filopodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EZR, PHF23, and LINC02693, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Filopodium assembly activity versus EZR in LUNG_NSCLC_LUAD (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EZR →	+1.330	+0.497	<.001	.009	3	6
STOMACH	PHF23 →	-0.837	-0.144	.009	.009	3	6
BREAST	LINC02693 →	-1.341	-0.329	<.001	.008	3	5
URINARY_TRACT	ZBED2 →	+5.170	+0.340	<.001	.002	3	5
PANCREAS	PFAS →	-1.232	-0.347	.003	.005	2	6
OVARY	DHX33 →	-0.993	-0.636	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046847 vs EZR — LUNG_NSCLC_LUAD

Explore this scatter interactively →