Phospholipid dephosphorylation

Across TCGA patient cohorts, RNA activity of the Phospholipid dephosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL10A, CLUH, and CNRIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid dephosphorylation activity versus RPL10A in GBM (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL10A →	-0.229	-0.049	<.001	<.001	3	8
LSCC	CLUH →	-0.352	-0.033	.001	.004	3	8
OV	CNRIP1 →	+0.606	+0.054	.001	<.001	3	8
GBM	RPL5 →	-0.264	-0.062	<.001	<.001	3	8
BRCA	SEPTIN2 →	+0.207	+0.029	<.001	<.001	3	8
OV	SNX9 →	+0.380	+0.042	.002	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046839 vs RPL10A — GBM

Explore this scatter interactively →