Phospholipid dephosphorylation

Across TCGA cell cohorts, RNA activity of the Phospholipid dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCP11L1, EXD1, and RUNX2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCP11L1 grouped by Phospholipid dephosphorylation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TCP11L1 →	+0.599	+0.593	.004	.003	3	4
BREAST	EXD1 →	+0.133	+0.559	.008	.008	3	4
BLOOD_Lymphoma	RUNX2 →	-2.867	-0.302	<.001	.007	3	4
OVARY	MAPK11 →	+1.087	+0.578	<.001	.003	3	4
BLOOD_Myeloma	PLEC →	-1.368	-1.101	.001	.007	3	4
SKIN	SPRED2 →	+0.476	+0.856	.004	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCP11L1 by Phospholipid dephosphorylation activity — LARGE_INTESTINE

Explore this box plot interactively →